Treatments

An up-to-date list of treatment guidelines is available to help with management of individual patients, or you can find detailed information about different antifungals and other treatments using the links below.

Antifungal drugs

The range of antifungals available to treat a given infection is often limited by cost, local approval, or by increasing rates of antifungal resistance. It is vital that more research is carried out to discover new classes of antifungals, as well as to optimise delivery systems to minimise the side-effects caused.

Itraconazole
Posaconazole
Voriconazole
Fluconazole
Econazole
Ketoconazole
Micafungin
Caspofungin
Anidulafungin
Amphotericin B
Nystatin
Natamycin
5-flucytosine
Terbinafine
Griseofulvin
In development Olorofim (F901318)
Rezafungin (CD101)
Nebulised amphotericin B
Ibrexafungerp (SCY-078)

Other types of treatment

While oral antifungals are the mainstay of managing most patients with serious fungal infections, some conditions may be suitable for surgery or immunotherapy. Other treatments (especially oral corticosteroids) are required for allergic conditions such as ABPA where the body over-reacts to the presence of fungi, although antifungals may play a role in reducing the fungal burden of the patient. Unfortunately no vaccines are currently approved for fungal conditions, but several are in development.

For self-care tips (including coping with side effects of antifungals) you may wish to direct your patient to the Aspergillosis Patients & Carers website.

Drug Interactions Pro app

Many antifungals interact with other drugs, for example by CYP3A4 inhibition. Use the Antifungal Drug Interactions app on your Android or Apple device, or through your web browser. A version aimed at patients is also available.


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