Around 1 in 6 patients admitted to ICU with influenza will go on to develop aspergillosis, which requires treatment with antifungals
- Read more about invasive fungal infections
- Read our factsheets about invasive aspergillosis, invasive mucormycosis, candidaemia, or Candida peritonitis
is a useful antigen biomarker produced by Aspergillus, Penicillium, Histoplasma, Fusarium and Talaromyces during invasive infections. Probable IA can be diagnosed when is found in the serum (OD ≥0.5) or (OD ≥0.8) of a patient with a pulmonary infection and a known risk factor. Testing is also good for diagnosing CBS aspergillosis.
But be aware of the following:
- A. flavus produces less than A. fumigatus
- Mould-active prophylaxis reduces sensitivity
- Sensitivity appears to be lower (~40%) in the serum of non-neutropaenic patients because are able to clear the antigen from the blood, but testing gives good sensitivity (88%)
Watch our lecture by Prof Malcolm Richardson (previous director of MRCM) explaining the performance of testing in different sample types and patient groups, and reasons for false positives (e.g. neonates, multiple myeloma, TPN) and false negative (e.g. mould-active prophylaxis, haemolysed samples, hyperbilirubinaemia, ). Our YouTube channel also has video protocols for using laboratory kits made by Dynamiker, Bio-Rad (Platelia), as well as the point-of-care test made by OLM Diagnostics (AspLFD).
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